AlphaGo is a top contender for the 2016 “Breakthrough of the Year” in Science’s annual survey of momentous scientific discoveries, developments, or trends. Voting continues through Sunday, December 4; click here to vote. At 14%, “AI Ups its Game” is second only to “Human embryos in a dish,” with 20% response, narrowly leading “Ripples in spacetime” with 13%. After voting closes on Sunday, a second round of voting will be conducted with the 5 finalists to pick the official winner, and the People’s Choice selection, along with Science editors’ pick, will be announced on December 22.